Episode 29: The Big Sick 2019
Author: Eoghan Colgan @eoghan_colgan
Special Guests: Soren Rudolph, Tim Harris, Philip Spinella, Caroline Leech, Niklas Nielson, Hermann Brugger & Matthieu Komorowski
27/02/19
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Guest Bios
Senior Consultant Anesthesiologist, trauma manager and prehospital doctor. Works at the University Hospital of Copenhagen, Rigshospitalet level 1 trauma center, Emergency Medical Services Copenhagen and HEMS Denmark.
Dedicated to trauma resuscitation, prehospital care and airway management.
Twitter: @sorenrudolph
Professor Tim Harris was born in the UK but has spent around half his life overseas. He trained in Emergency Medicine and Intensive care medicine in Australia, and in pre-hospital Medicine in Australia and the UK. He has worked in 43 hospitals in 11 countries and mixed training with travel with volunteer work in Africa, India and Samoa. He has worked at Barts Health for 10 years and was appointed Professor Emergency Medicine at QMUL and BH in 2012. He divides his academic time between teaching and research. His main interests are resuscitation, ultrasound, and point of care testing but most academic time is working to facilitate large multicentre studies at BH. BH research team have run 14 portfolio studies and published over 40 scientific papers in their four year existence. He is CLRN lead for North Thames and chairs the London Emergency Medicine Academic committee.
Dr Philip C. Spinella is a pediatric intensivist and Director of the Critical Care Translational Research Program at Washington University in St Louis School of Medicine and the St Louis Children’s Hospital. He served as an active duty US Army physician for 12 years, which included a 1-year deployment to Iraq. He continues to serve as a Consultant to the US Army Blood Research Program and is the Chair of the Steering Committee for the Norwegian Navy Blood Far Forward Research Program. His publications are in the area of blood component and whole blood resuscitation for traumatic hemorrhagic shock, clinical and translational research regarding the effects of RBC storage duration on outcomes, immunology and coagulation, and coagulation monitoring by thromboelastography. He is also an Affiliate Investigator at the Blood Systems Research Institute in San Francisco, CA.
Caroline Leech is a Consultant in Emergency Medicine at University Hospital Coventry (UK). She has 20 years experience of pre-hospital care primarily in London and the West Midlands. Caroline is an Associate Editor of the Emergency Medicine Journal, Executive of the Faculty of Pre-Hospital Care (RCSEd), Vice-Chair of the charity TraumaCare, Director of the West Midlands Emergency Surgical Skills Course, and Deputy Clinical Lead of The Air Ambulance Service.
Niklas Nielsen is a staff specialist in Anaesthesia and Intensive Care at Helsingborg Hospital and associate professor at the Department of Clinical Sciences, Lund University, Sweden. His research interest is on various aspects of post-cardiac arrest care with focus on targeted temperature management, biomarkers for prediction, trial methodology, trial conduct and follow-up. He was PI for the recent TTM-trial 33°C versus 36°C and is currently leading the TTM2-trial www.ttm2trial.org. He is involved in the Anaesthesia, Intensive Care and Emergency Medicine programs at Lund University.
Dr Brugger is a general practitioner and emergency physician. He is the founder and head of the EURAC Institute of Mountain Emergency Medicine in Bolzano, Italy. He has published extensively on various topics in mountain emergency medicine including several landmark publications on avalanche rescue and accidental hypothermia. He has received numerous scientific awards. He is an associate Editor of High Altitude Medicine and Biology, a guest lecturer at the University of Padova, as well as an associate Professor and lecturer at the Innsbruck Medical University.Outside his research activities and hospital work He is a mountain rescue physician for the Mountain Rescue Organization of South Tyroland has performed more than 2000 mountain rescue operations. He is an enthusiastic mountaineer and ski-tourer with several ascents in Europe, the Americas and Asia.
Matthieu holds full board certification in anesthesiology and critical care in both France and the UK. He was previously a research fellow at the European Space Agency and holds additional qualifications in mountain, diving and hyperbaric medicine. He worked with the NASA Human Research Program and developed simplified anesthesia protocols for future space exploration missions. He currently pursues a PhD in machine learning applied to intensive care at Imperial College London and the Massachusetts Institute of Technology. For his work, he received several awards including the first prize of Research and Innovation of the British Royal Society of Medicine. He is an affiliate of Harvard University where he teaches reinforcement learning in healthcare.
Show Notes
'The Big Sick' is a conference about critical care and emergency medicine. The overall theme is the resuscitation of the sickest patients, specifically what to do during the first hours after the critically ill or injured patient is presented to us. The speakers are some of the biggest names in critical care providing the latest research and thinking in their fields.
Take Home Points
Soren Rudolph
Only a few select patients will need immediate intubation
Most can take time and think carefully about how best to proceed
Resuscitation before intubation
Optimise the conditions that can kill a patient during intubation
Hypovlaemia
Severe Acidaemia
Hypoxia
Haemodynamic Compromise
Fluid resuscitation prior to intubation
Pressors prior to intubation (push-dose +/_ infusion)
Dose anaesthetics smart
Low on sedatives
High on paralytics
There is a role for awake intubation in this setting
Hypoxia
Pre-oxygenation
Peri-intubation oxygenation (through all phases of the intubation) – including apneic oxygenation
Delayed Sequence Intubation
Ketamine sedate patient to aid oxygenation prior to intubation
Tim Harris
In haemorraghic shock we tend to focus resuscitation on restoring coagulation first and then perfusion
Blood products – restore coagulation proteins a and haemoglobin
Tranexamic acid to reduce fibrinolysis
Lower volume than volume lost – permissive hypotension
Less pressure on clotting vessels
We don’t how long we can leave patients ‘hypotensive’
The longer we leave them in this state:
Increased incidence of organ failure
Particularly kidneys
We don’t know what the right BP to aim for is
One method is using brain perfusion as a guide – are they conscious and orientated?
If so then they likely have enough perfusion for that first 30-60mins of resuscitation
Not always easy in intubated/distracted patient
His current practice:
Awake Patients:
Give blood products until they respond
Intubated/Ventilated depends on age:
Elderly: 100-110 SBP
Middle-aged: 90 - 100
Young: 80 - 90
Will probably accept lower if awake
Most evidence on permissive hypotension is old – there is need for a major trial to define ‘how low to go and how long for’
Philip Spinella
Whole blood is the optimal blood product for traumatic shock
Comparing whole blood to 1:1:1 blood products, whole blood is:
More efficacious as blood components are diluted by citrate and added solutions
safer (Group O) as there is no risk of fatal haemolytic reaction
logistically easier to provide (if withdrawn fresh)
storable for 14 days (cold-stored whole blood) compared to 5 days for platelets
The future might be dried whole blood
Currently there is dried plasma
There will soon to be a dried platelet product
There is a synthetic red cell product in development
CAROLINE LEECH
Three indications to perform pre-hospital amputation:
Patient is trapped and periarrest – amputation will allow extraction and resuscitation
Scene safety emergency – e.g. rising floow-water, chemical incident and it is essential; to extract quickly to avoid death
In a multi-trauma situation where you need to amputate the limb of a deceased person to access the living
Procedure:
Traditional guillotine procedure – not aiming for flap, rather a straight cut through
Aim for fracture sites in a limb (reduces the time on cutting bone)
Sedate with Ketamine
Use a commercial tourniquet, can guide sedation on how much discomfort the tourniquet causes
Scalpel for skin – typically more then one as they can blunt easily
Trauma shears to cut muscle and sot tissue
Gigli saw with wire to cut bone
After patient out – ensure rapid haemorrhage control
Make sure tourniquet tight
Artery forceps for large vessels
Haemostatic gauze on stump with emergency bandage
Carry on patient resuscitation (RSI, fluid resus etc)
Justin Brede
Inflate a balloon in the aorta in medical cardiac arrest = down prioritize the lower body and centralize blood flow to heart and brainb
A lot of animal studies and growing human studies
Current pilot prehospital study happening in Norway
Logistics:
Arrive on scene
First responders – establish Advanced Life Support
Then proceed to REBOA
Takes about 10-12 minutes from decision to occlusion
ALS continues
Benefits: they are seeing a dramatic increase in ROSC with extraordinary cases of survival
The full data on long-term benefits yet to be established
Niklas Nielson
What the TTM trial showed:
No demonstrable difference in survival or quality of life between patients cooled to 33 degrees and those cooled to 36 degrees post-cardiac arrest
Cooling has been downgraded in priority but there is still debate on how best to manage these cases
Practice varies widely
Now performing a phase 3 trial comparing rapid cooling to 33 degrees to normothermia (temp management if starts to have a fever)
Uncertainly still exists around whether cooling helps at all:
Hawthorne Effect – a general increase in attention from the doctors may be having an impact rather than the treatment itself?
Hermann Brugger
Most important predictor of survival is grade of burial:
Not fully buried – survival rate >90%
Fully buried (head under snow) – survival rate ~50%
If fully buried then duration become very important
<18mins then chance of survival is >90%
After this survival drops precipitously
Most die from asphyxia (around 75% of all victims)
If they can breathe under snow they could survive for a few hours
If there is a connection to outside world then they can survive much longer (record is 48 hours)
The density of the snow can impact survival (which varies between nations)
Hypoxia can be affected by quality of snow
Higher the density the greater the lack of oxygen
Low density: there is an increase in CO2 (unsure why)
This may help as it hastens drop in temperature which is protective
Prognostication Factors for survival:
Duration of burial
Patency of airway
an airpocket in front of mouth and nose of victim is a positive sign (rewarm these patients)
This indicates they were able to breathe after burial
Serum potassium (<8mmol) and core temperature (30 degrees) are now the cutoff’s for extracorporeal rewarming
Overall survival has improved
The number of total deaths has stayed the same but the number of people exposed has greatly increased
Matthieu Komorowski
Some of the considerations for medical support for a manned mission:
900 day mission (500 on surface of mars)
Remote from help and crew autonomy
Exposed to extreme environments may precipitate illness unique to space on top of all the usual ones (IHD, cancer etc)
Space-specific conditions:
Cardiovascular system becomes deconditioned
Bone loss in weightlessness (may not be able to stand on mars when arrive)
Radiation exposure (not protected by earth atmosphere)
Increased risk of infection in space:
Immune system is depressed in space (chronic stress)
New germs can appear
New strains are discovered on the filters of international space station
How will our immune system and antibitics reacte top them
Everything recirculates in the space station (difficult to clean)
Ethical Consideration: at what point is it futile to continue treatment and better to palliate
There is a limit to what can be brought with them
Do they bring dialysis machines or ventilators?
Need to consider the impact on resources and risk to other crew members when treating certain conditions